Megaloblastic Anaemia Following Anticonvulsants
نویسندگان
چکیده
منابع مشابه
Aminoaciduria and megaloblastic anaemia.
Urinary amino-acid chromatograms from 23 patients with megaloblastic anaemia have been studied before and after therapy. The most consistent abnormality was an increased taurine or increased taurine/glycine ratio. This was not related directly to deficiency of vitamin B(12) or folic acid or to the degree of anaemia.
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IN 1877 Muller described a marked bronzed discoloration of the skin in some patients considered to have pernicious anaemia. This observation, confirmed later by Immerman (1879) is likely to be the first record of an association between a macrocytic type of anemia and haemochromatosis. Since that time French (1909), Roth (1915), Bork (1928), Cain (1940), Hotz (1944) and Harvier and Mallarme (193...
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1. Serial measurements of serum potasssium and total-body potassium were made on eighteen patients with megaloblastic anaemia before the start of therapy and during the period of recovery. 2. In those patients who presented with an initial packed cell volume of less than 25%, a mean decrease in serum potassium of 0.4 mmol/1 occurred on average with 2.5 days of the start of therapy. This was f...
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Ten patients with severe megaloblastic anaemia were studied to investigate whether the causative metabolic defects might predispose them to lactic or other acidosis. One patient had compensated acidosis with hyperlactataemia before treatment but there were obvious causes other than anaemia. No other patient developed an acidosis. Neither anaemia per se nor the metabolic defects of vitamin B(12)...
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Examination in Hospital.-He was febrile and pale with a smooth tongue. No splenic enlargement was detected. There were no significant neurological signs. The haemoglobin level was 33 per cent., red blood count 1,360,000/c.mm., colour index 1-27, average red cell diameter 7 8,t, and white blood count 5,800/c.mm. There was marked anisocytosis, poikilocytosis, scanty platelets, and 1 per cent. ret...
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ژورنال
عنوان ژورنال: BMJ
سال: 1955
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.4924.1247